| ZFIN ID: ZDB-EXP-260406-5 |
Experiment Conditions Description: cancer xenotransplantation, chemical treatment by environment: olaparib, chemical treatment by environment: temozolomide
| cancer xenotransplantation |
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| Name: | cancer xenotransplantation |
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| Synonyms: | |
| Definition: | Xenotransplantation condition in which cancer cells are injected or grafted into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000236] |
| chemical treatment by environment: olaparib |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | olaparib |
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| Synonyms: | 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one, AZD-2281, AZD2281, KU59436, Lynparza, olaparib |
| Definition: | A member of the class of N-acylpiperazines obtained by formal condensation of the carboxy group of 2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoic acid with the free amino group of N-(cyclpropylcarbonyl)piperazine; used to treat advanced ovarian cancer. |
| Ontology: | ChEBI [CHEBI:83766] ( EBI ) |
| chemical treatment by environment: temozolomide |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | temozolomide |
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| Synonyms: | 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide, 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide, 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide, 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide, 8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one, BRN 5547136, CCRG 81045, CCRG-81045, CCRIS 8996, M & B 39831, M&B 39831, MB 39831, methazolastone, NSC 362856, Sch 52365, Temodal, Temodar, temozolomida, temozolomide, temozolomidum, TMZ |
| Definition: | An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma. |
| Ontology: | ChEBI [CHEBI:72564] ( EBI ) |
| Publication: | Hayes et al., 2025 |
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