| ZFIN ID: ZDB-EXP-260310-7 |
Experiment Conditions Description: chemical treatment by environment: Z-Val-Ala-Asp(OMe)-CH2F, physical alteration: retina
| chemical treatment by environment: Z-Val-Ala-Asp(OMe)-CH2F |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | Z-Val-Ala-Asp(OMe)-CH2F |
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| Synonyms: | N-[(benzyloxy)carbonyl]-L-valyl-N-[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]-L-alaninamide, pan-caspase inhibitor, Z-L-Val-L-Ala-L-Asp(OMe)-CH2F, Z-VAD(OMe)-FMK, Z-VAD-FMK, Z-Val-Ala-Asp(OMe)-fluoromethyl ketone, Z-Val-Ala-Asp(OMe)-FMK |
| Definition: | A tripeptide consisting of Z-Val-Ala-Asp(OMe) in which the C-terminal OH group has been replaced by a fluoromethyl group. An irreversible pan-caspase inhibitor. |
| Ontology: | ChEBI [CHEBI:137045] ( EBI ) |
| physical alteration: retina |
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| Name: | physical alteration |
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| Synonyms: | |
| Definition: | Experimental condition in which an anatomical structure, cell, or organ has sustained targeted physical change, usually through the use of an instrument. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000229] |
| Name: | retina |
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| Synonyms: | retinas |
| Definition: | Multi-tissue structure that contains the retinal neural layer and the retinal pigmented epithelium, and develops from the optic cup. |
| Ontology: | Anatomy Ontology [ZFA:0000152] |
| Publication: | Mitra et al., 2022 |
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