| ZFIN ID: ZDB-EXP-260122-10 |
Experiment Conditions Description: bacterial treatment by injection: Mycobacterium marinum M, chemical treatment by injection: Recombinant Tumor Necrosis Factor TNF alpha (Zebrafish), chemical treatment by environment: telaglenastat
| bacterial treatment by injection: Mycobacterium marinum M |
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| Name: | bacterial treatment by injection |
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| Synonyms: | |
| Definition: | Bacterial treatment where the bacteria are injected into the fish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000230] |
| Name: | Mycobacterium marinum M |
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| Synonyms: | Mycobacterium marinum str. M, Mycobacterium marinum strain M |
| Definition: | |
| Ontology: | Taxonomy for ZECO [NCBITaxon:216594] |
| chemical treatment by injection: Recombinant Tumor Necrosis Factor TNF alpha (Zebrafish) |
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| Name: | chemical treatment by injection |
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| Synonyms: | |
| Definition: | Chemical treatment in which the chemical is injected into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000237] |
| Name: | Recombinant Tumor Necrosis Factor TNF alpha (Zebrafish) |
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| Synonyms: | TNF-a, TNFalpha |
| Definition: | Tumor necrosis factor alpha is a member of the TNF Superfamily. It is produced chiefly by activated macrophages, but it is produced also by a broad variety of cell types including lymphoid cells, mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and neuronal tissue. Protein Sequence:AAIHLTGGYN SESKTLDWRD DQDQAFSSGG LKLVNREIII PDDGIYFVYS QVSLHISCTS ELTEEQVLMS HAVMRFSESY GGKKPLFSAI RSICTQEPES ENLWYNTIYL GAAFHLREGD RLGTDTTTAL LPMVENDNGK TFFGVFGL |
| Ontology: | ChEBI [CHEBI:197439] ( EBI ) |
| chemical treatment by environment: telaglenastat |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | telaglenastat |
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| Synonyms: | 2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide, CB-839, N-[6-[4-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]butyl]pyridazin-3-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide, telaglenastat, telaglenastatum |
| Definition: | Telaglenastat is an orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. |
| Ontology: | ChEBI [CHEBI:231605] ( EBI ) |
| Publication: | Roca et al., 2022 |
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