| ZFIN ID: ZDB-EXP-251015-1 |
Experiment Conditions Description: chemical treatment by environment: EC 2.7.11.13 (protein kinase C) inhibitor, chemical treatment by environment: phorbol 13-acetate 12-myristate
| chemical treatment by environment: EC 2.7.11.13 (protein kinase C) inhibitor |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | EC 2.7.11.13 (protein kinase C) inhibitor |
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| Synonyms: | ATP:protein phosphotransferase (diacylglycerol-dependent) inhibitor, ATP:protein phosphotransferase (diacylglycerol-dependent) inhibitors, calcium-dependent protein kinase C inhibitor, calcium-dependent protein kinase C inhibitors, calcium-independent protein kinase C inhibitor, calcium-independent protein kinase C inhibitors, calcium/phospholipid dependent protein kinase inhibitor, calcium/phospholipid dependent protein kinase inhibitors, cPKC inhibitor, cPKC inhibitors, cPKCalpha inhibitor, cPKCalpha inhibitors, cPKCbeta inhibitor, cPKCbeta inhibitors, cPKCgamma inhibitor, cPKCgamma inhibitors, EC 2.7.11.13 (protein kinase C) inhibitors, EC 2.7.11.13 inhibitor, EC 2.7.11.13 inhibitors, nPKC inhibitor, nPKC inhibitors, nPKCdelta inhibitor, nPKCdelta inhibitors, nPKCepsilon inhibitor, nPKCepsilon inhibitors, nPKCeta inhibitor, nPKCeta inhibitors, nPKCtheta inhibitor, nPKCtheta inhibitors, PKC inhibitor, PKC inhibitors, Pkc1p inhibitor, Pkc1p inhibitors, PKCalpha inhibitor, PKCalpha inhibitors, PKCbeta inhibitor, PKCbeta inhibitors, PKCdelta inhibitor, PKCdelta inhibitors, PKCepsilon inhibitor, PKCepsilon inhibitors, PKCgamma inhibitor, PKCgamma inhibitors, PKCzeta inhibitor, PKCzeta inhibitors, PKN3 inhibitor, PKN3 inhibitors, protein kinase C (EC 2.7.11.13) inhibitor, protein kinase C (EC 2.7.11.13) inhibitors, protein kinase C inhibitor, protein kinase C inhibitors, protein kinase Cepsilon inhibitor, protein kinase Cepsilon inhibitors, STK24 inhibitor, STK24 inhibitors |
| Definition: | An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13). |
| Ontology: | ChEBI [CHEBI:37700] ( EBI ) |
| chemical treatment by environment: phorbol 13-acetate 12-myristate |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | phorbol 13-acetate 12-myristate |
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| Synonyms: | (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate, 12-O-tetradecanoylphorbol 13-acetate, 12-tetradecanoylphorbol 13-acetate, phorbol 12-myristate 13-acetate, phorbol 12-tetradecanoate 13-acetate, phorbol-12-myristate-13-acetate, PMA, tetradecanoylphorbol acetate, TPA |
| Definition: | A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types. |
| Ontology: | ChEBI [CHEBI:37537] ( EBI ) |
| Publication: | Liu et al., 2018 |
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