| ZFIN ID: ZDB-EXP-250408-4 |
Experiment Conditions Description: chemical treatment by environment: ponatinib, chemical treatment by environment: dipyridamole
| chemical treatment by environment: ponatinib |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | ponatinib |
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| Synonyms: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, AP 24534, AP-24534, AP24534, ponatinib, ponatinibum |
| Definition: | A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline. It is a multi-target tyrosine kinase inhibitor that targets ABL, SRC, FGFR, and others and was designed to overcome the resistance of BCR-ABL mutation to imatinib, in particular the gatekeeper mutation ABL(T315I). |
| Ontology: | ChEBI [CHEBI:78543] ( EBI ) |
| chemical treatment by environment: dipyridamole |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | dipyridamole |
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| Synonyms: | 2,2',2'',2'''-[(4,8-dipiperidin-1-ylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol, Cardoxin, Cleridium 150, Curantyl, dipiridamol, Dipyridamine, dipyridamole, dipyridamolum, Dipyudamine, Dypyridamol, Persantin |
| Definition: | A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots. |
| Ontology: | ChEBI [CHEBI:4653] ( EBI ) |
| Publication: | Yu et al., 2024 |
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