| ZFIN ID: ZDB-EXP-250320-1 |
Experiment Conditions Description: chemical treatment by environment: IWR-1-endo, chemical treatment by environment: IWR-1-exo, chemical treatment by environment: O-(chloroacetylcarbamoyl)fumagillol
| chemical treatment by environment: IWR-1-endo |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | IWR-1-endo |
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| Synonyms: | 4-[(3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide, IRW1 |
| Definition: | A dicarboximide having an endo bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group. |
| Ontology: | ChEBI [CHEBI:62882] ( EBI ) |
| chemical treatment by environment: IWR-1-exo |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | IWR-1-exo |
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| Synonyms: | 4-[(3aR,4R,7S,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide |
| Definition: | A dicarboximide having an exo bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group. It is a weak axin stabilizer, an analogue of IWR-1-endo. |
| Ontology: | ChEBI [CHEBI:62883] ( EBI ) |
| chemical treatment by environment: O-(chloroacetylcarbamoyl)fumagillol |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | O-(chloroacetylcarbamoyl)fumagillol |
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| Synonyms: | (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl (chloroacetyl)carbamate, (CHLOROACETYL)CARBAMIC ACID (3R,4S,5S,5R)-5-METHOXY-4-[(2R,3R)-2-METHYL-3-(3-METHYL-2-BUTENYL)OXIRANYL]-1-OXASPIRO[2.5]OCT-6-YL ESTER, Agm 1470, AGM-1470, DRG-0148, O-chloroacetylcarbamoylfumagillol, TNP 470, TNP-470 |
| Definition: | A carbamate ester that is fumagillol in which the hydroxy group has been converted to the corresponding N-(chloroacetyl)carbamate derivative. |
| Ontology: | ChEBI [CHEBI:90748] ( EBI ) |
| Publication: | Paolini et al., 2023 |
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