| ZFIN ID: ZDB-EXP-180920-9 |
Experiment Conditions Description: high fat, chemical treatment by environment: pravastatin, chemical treatment by environment: benzo[a]pyrene, chemical treatment by environment: ethanol
| high fat |
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| Name: | high fat |
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| Synonyms: | |
| Definition: | Fat content condition in which the amount of fat in the diet is elevated. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000122] |
| chemical treatment by environment: pravastatin |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | pravastatin |
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| Synonyms: | (+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid, (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid, pravastatin, pravastatin acid, pravastatina, pravastatine, pravastatinum |
| Definition: | A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin. |
| Ontology: | ChEBI [CHEBI:63618] ( EBI ) |
| chemical treatment by environment: benzo[a]pyrene |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | benzo[a]pyrene |
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| Synonyms: | (B(a)P), 3,4-Benzopyrene, 3,4-Benzpyrene, 3,4-BP, Benzo(a)pyrene, Benzo[a]pyrene, benzo[def]chrysene, benzo[pqr]tetraphene, Benzpyrene, BP |
| Definition: | An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. |
| Ontology: | ChEBI [CHEBI:29865] ( EBI ) |
| chemical treatment by environment: ethanol |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | ethanol |
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| Synonyms: | 1-hydroxyethane, [CH2Me(OH)], [OEtH], Aethanol, Aethylalkohol, alcohol, alcohol etilico, alcool ethylique, Alkohol, C2H5OH, Dehydrated ethanol, etanol, ethanol, Ethyl alcohol, EtOH, hydroxyethane, Methylcarbinol, spiritus vini |
| Definition: | A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group. |
| Ontology: | ChEBI [CHEBI:16236] ( EBI ) |
| Publication: | Imran et al., 2018 |
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