Search Ontology:
ChEBI
Bravizine: N-[4-[(4-hydroxy-3-tert-butylphenyl)methyl]-1-piperazinyl]benzamide
- Term ID
- CHEBI:746918
- Synonyms
-
- Bravizine
- Definition
- A synthetic small-molecule compound designed as a β-arrestin–biased partial agonist of the dopamine D2 receptor. Structurally, it is a substituted benzamide containing a piperazinyl linkage and a tert-butylphenol moiety. Bravizine was developed through AI-augmented ligand optimization to selectively modulate D2R signaling by favoring β-arrestin recruitment over G-protein activation, with potential therapeutic application in the treatment of tardive dyskinesia.
- References
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from Bravizine: N-[4-[(4-hydroxy-3-tert-butylphenyl)methyl]-1-piperazinyl]benzamide
Phenotype where environments contain Bravizine: N-[4-[(4-hydroxy-3-tert-butylphenyl)methyl]-1-piperazinyl]benzamide
Phenotype modified by environments containing Bravizine: N-[4-[(4-hydroxy-3-tert-butylphenyl)methyl]-1-piperazinyl]benzamide
Phenotype affecting Bravizine: N-[4-[(4-hydroxy-3-tert-butylphenyl)methyl]-1-piperazinyl]benzamide
Human Disease Model