Search Ontology:
ChEBI
Sotuletinib
- Term ID
- CHEBI:746976
- Synonyms
-
- BLZ-945
- blz945
- Definition
- Sotuletinib is an inhibitor of colony stimulating factor 1 receptor (CSF-1R; CSF1R), with potential antineoplastic activity. It selectively binds to CSF1R expressed on tumor-associated macrophages (TAMs), blocks the activity of CSF1R, and inhibits CSF1R-mediated signal transduction pathways. This inhibits the activity and proliferation of TAMs, and reprograms the immunosuppressive nature of existing TAMs. Altogether, this reduces TAM-mediated immune suppression in the tumor microenvironment, re-activates the immune system, and improves anti-tumor cell responses mediated by T-cells.
- References
-
- cas:953769-46-5
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from Sotuletinib
Phenotype where environments contain Sotuletinib
Phenotype modified by environments containing Sotuletinib
Phenotype affecting Sotuletinib
Human Disease Model