Search Ontology:
ChEBI
AZD3965
- Term ID
- CHEBI:234329
- Synonyms
-
- 5-[(4S)-4-hydroxy-4-methyl-1,2-oxazolidine-2-carbonyl]-3-methyl-6-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}-1-(propan-2-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
- 5-{[(4S)-4-hydroxy-4-methyl-1,2-oxazolidin-2-yl]carbonyl}-3-methyl-6-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}-1-(propan-2-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
- AZD 3965
- AZD-3965
- Definition
- A thienopyrimidine that is thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione substituted by isopropyl, methyl, (4S)-4-hydroxy-4-methyl-1,2-oxazolidine-2-carbonyl, and [5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl groups at positions 1, 3, 5, and 6, respectively. It is an inhibitor of monocarboxylate transporter 1 (Ki = 1.6 nM), and was previously in phase I clinical trials for the treatment of lymphomas and solid tumours.
- References
-
- CAS:1448671-31-5
- PMID:24277449
- PMID:25281618
- PMID:28385782
- PMID:28923861
- PMID:29050199
- PMID:29674138
- PMID:30617815
- PMID:31010842
- PMID:31823112
- PMID:31937921
- PMID:32076124
- PMID:32203218
- PMID:32529599
- PMID:32604836
- PMID:32833237
- PMID:33540599
- PMID:33963018
- PMID:35011413
- PMID:35618788
- PMID:36342616
- PMID:36652553
- PMID:36884092
- PMID:38140029
- PMID:39465441
- PMID:39810069
- PMID:39810250
- PMID:40043615
- PMID:40347782
- PMID:40400476
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from AZD3965
Phenotype where environments contain AZD3965
Phenotype modified by environments containing AZD3965
Phenotype affecting AZD3965
Human Disease Model