Search Ontology:
ChEBI
GSK-923295
- Term ID
- CHEBI:234356
- Synonyms
-
- 3-chloro-N-[(2S)-1-[(N,N-dimethylglycyl)amino]-3-(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)propan-2-yl]-4-(propan-2-yloxy)benzamide
- GSK 295
- GSK 923295
- GSK 923295A
- GSK-295
- GSK-923295A
- GSK295
- GSK923295
- GSK923295A
- Definition
- An imidazopyridine that is imidazo[1,2-a]pyridine substituted by 4-{(2S)-2-[3-chloro-4-(propan-2-yloxy)benzamido]-3-[(N,N-dimethylglycyl)amino]propyl}phenyl, and (1S)-1-hydroxyethyl groups at positions 2 and 8, respectively. It is an allosteric inhibitor of centromere-associated protein-E (CENP-E) kinesin motor ATPase activity (Ki = 3.2 nM and 1.6 nM for human and canine CENP-E motordomains, respectively).
- References
-
- CAS:1088965-37-0
- DrugBank:DB06097
- LINCS:LSM-45692
- PMID:20167803
- PMID:21584937
- PMID:22020315
- PMID:22948716
- PMID:24900171
- PMID:25725449
- PMID:26320186
- PMID:27368372
- PMID:29982103
- PMID:30681497
- PMID:31530389
- PMID:32351712
- PMID:32442423
- PMID:32679092
- PMID:32698529
- PMID:33237480
- PMID:33804489
- PMID:35037651
- PMID:37728741
- PMID:38258067
- PMID:39327243
- PMID:39701545
- PMID:39737806
- PMID:39818172
- Patent:WO2010102157
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from GSK-923295
Phenotype where environments contain GSK-923295
Phenotype modified by environments containing GSK-923295
Phenotype affecting GSK-923295
Human Disease Model