trandolapril

Term ID

CHEBI:9649

Synonyms

• (2S,3aR,7aS)-1-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester
• (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid
• Gopten
• Mavik
• Odrik
• RU 44570
• RU-44570
• RU44570
• trandolapril
• trandolaprilum

Definition

A heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension.

References

• cas:87679-37-6
• chemspider:4588590
• drugbank:DB00519
• drugcentral:2712
• hmdb:HMDB0014660
• kegg.drug:D00383
• patent:KR20080046630
• patent:WO2006014916
• pubmed:1648489
• pubmed:19337528
• pubmed:22247843
• pubmed:23784370
• pubmed:24835355
• pubmed:25802524
• pubmed:25864194
• pubmed:26915813
• pubmed:27215243
• pubmed:29319234
• pubmed:32964020
• pubmed:33660934
• pubmed:3383998
• pubmed:34172790
• pubmed:8515499
• pubmed:8515500
• pubmed:8515501
• pubmed:8515502
• pubmed:8515504
• pubmed:9770740
• reaxys:8655766
• wikipedia.en:Trandolapril

Ontology

ChEBI  ( EBI )