4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol

Term ID

CHEBI:82569

Synonyms

4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanol
4-[methyl(nitroso)amino]-1-(3-pyridyl)-1-butanol
4-[methyl(nitroso)amino]-1-(pyridin-3-yl)butan-1-ol
N-[4-hydroxy-4-(pyridin-3-yl)butyl]-N-methylnitrous amide
NNAL

Definition

A member of the class of nitrosamines that is butan-1-ol substituted by a pyridin-3-yl group at position 1 and by a methyl(nitroso)amino group at position 4. It is a major metabolite of nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which is a carcinogen found in tobacco and responsible for inducing lung cancer in smokers.

References

cas:76014-81-8
chemspider:94646
hmdb:HMDB0041809
kegg.compound:C19574
metacyc.compound:CPD-21235
pubmed:21154658
pubmed:24521204
pubmed:24648246
pubmed:25218107
pubmed:25544129
pubmed:26595795
pubmed:26744252
pubmed:27632782
pubmed:27834821
pubmed:29131934
pubmed:29186507
pubmed:29390940
pubmed:29460622
pubmed:29475963
pubmed:29651838
pubmed:29739005
pubmed:30136502
pubmed:30714728
pubmed:31307193
pubmed:31470076
pubmed:31578206
pubmed:31833541
pubmed:32716026
pubmed:32944094
pubmed:33210550
pubmed:8634661

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol

Phenotype where environments contain 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol

Phenotype modified by environments containing 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol

Phenotype affecting 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol

Human Disease Model