lopinavir

Term ID

CHEBI:31781

Synonyms

• (2S)-N-[(2S,4S,5S)-5-{[(2,6-dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
• Lopinavir

Definition

A dicarboxylic acid diamide that is amphetamine is substituted on nitrogen by a (2,6-dimethylphenoxy)acetyl group and on the carbon α- to nitrogen by a (1S,3S)-1-hydroxy-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1-yl)butanoyl]amino}-4-phenylbutyl group. An antiretroviral of the protease inhibitor class, it is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir.

References

• cas:192725-17-0
• drugbank:DB01601
• drugcentral:1601
• hmdb:HMDB0015539
• kegg.compound:C12871
• kegg.drug:D01425
• lincs.smallmolecule:LSM-6027
• pdb-ccd:AB1
• pubmed:24014186
• pubmed:24518130
• pubmed:24566184
• pubmed:24805184
• pubmed:24906762
• pubmed:24958908
• pubmed:25120613
• reaxys:9309881

Ontology

ChEBI  ( EBI )