ZFIN ID: ZDB-PUB-991020-9
Compartmentalized expression of zebrafish ten-m3 and ten-m4, homologues of the Drosophila ten(m)/odd Oz gene, in the central nervous system
Mieda, M., Kikuchi, Y., Hirate, Y., Aoki, M., and Okamoto, H.
Date: 1999
Source: Mechanisms of Development 87(1-2): 223-227 (Journal)
Registered Authors: Aoki, Yasunobu, Hirate, Yoshikazu, Kikuchi, Yutaka, Mieda, Michihiro, Okamoto, Hitoshi
Keywords: zebrafish; ten-m; teneurin; ten(m)/odd Oz (dz); DOC4; CNS; rhombomere; mesencephalon; diencephalon; midbrain/hindbrain boundary; EGF-repeat; tenascin
MeSH Terms: Amino Acid Sequence; Animals; DNA, Complementary/analysis; Drosophila; Drosophila Proteins* (all 19) expand
PubMed: 10495292 Full text @ Mech. Dev.
FIGURES   (current status)
ABSTRACT
Zebrafish ten-m3 and ten-m4 encode proteins highly similar to the product of Drosophila pair-rule gene ten(m)/odd Oz (odz). Their products contain eight epidermal growth factor (EGF)-like repeats that resemble mostly those of the extracellular matrix molecule tenascin. During segmentation period, ten-m3 is expressed in the somites, notochord, pharyngeal arches, and the brain, while expression of ten-m4 is mainly restricted to the brain. In the developing brain, ten-m3 and ten-m4 expression delineates several compartments. Interestingly, ten-m3 and ten-m4 show expression patterns complementary to each other in the developing forebrain and midbrain along both rostrocaudal and dorsoventral axes, depending on developmental stages and locations.
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