PUBLICATION
Differential expression of Tbx4 and Tbx5 in zebrafish fin buds
- Authors
- Tamura, K., Yonei-Tamura, S., and Belmonte, J.C.
- ID
- ZDB-PUB-991020-7
- Date
- 1999
- Source
- Mechanisms of Development 87(1-2): 181-184 (Journal)
- Registered Authors
- Izpisúa Belmonte, Juan Carlos
- Keywords
- T-box; Tbx4; Tbx5; zebrafish; gene expression; embryogenesis; fin bud
- MeSH Terms
-
- Amino Acid Sequence
- Animal Structures/metabolism*
- Animals
- Avian Proteins*
- Eye/embryology
- Gene Expression Regulation, Developmental*
- In Situ Hybridization
- Molecular Sequence Data
- Phylogeny
- Sequence Homology, Amino Acid
- T-Box Domain Proteins/genetics
- T-Box Domain Proteins/metabolism*
- Time Factors
- Zebrafish
- Zebrafish Proteins*
- PubMed
- 10495283 Full text @ Mech. Dev.
Citation
Tamura, K., Yonei-Tamura, S., and Belmonte, J.C. (1999) Differential expression of Tbx4 and Tbx5 in zebrafish fin buds. Mechanisms of Development. 87(1-2):181-184.
Abstract
In here we report the identification of two new members of the T-box gene family, zf-tbx5 and zf-tbx4, from the Zebrafish, Danio rerio. The amino acid sequences within the T-box domain share high homology with the mouse, chick, and newt orthologs. Whole mount in situ hybridization revealed specific expression of these genes in the eye and Fin buds. zf-tbx5 expression is restricted to the pectoral Fin bud, whilst zf-tbx4 transcripts are confined in the pelvic Fin bud. These results reveal the conserved expression pattern of Tbx5 and Tbx4 during appendage development in all animal species studied to date.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping