PUBLICATION
Expression of a zebrafish iroquois homeobox gene, Ziro3, in the midline axial structures and central nervous system
- Authors
- Tan, J.T., Korzh, V., and Gong, Z.Y.
- ID
- ZDB-PUB-991020-6
- Date
- 1999
- Source
- Mechanisms of Development 87(1-2): 165-168 (Journal)
- Registered Authors
- Gong, Zhiyuan, Korzh, Vladimir
- Keywords
- cerebellum; chordo-neural hinge; CNS; interneurons; motoneurons; rhombomere 6
- MeSH Terms
-
- Rhombencephalon/metabolism
- Telencephalon/metabolism
- Gene Expression Regulation, Developmental*
- Diencephalon/metabolism
- Molecular Sequence Data
- DNA, Complementary/metabolism
- Cerebellum/metabolism*
- Time Factors
- Zebrafish Proteins*
- Amino Acid Sequence
- Sequence Homology, Amino Acid
- Animals
- Mesencephalon/metabolism
- Zebrafish
- Homeodomain Proteins/genetics
- Homeodomain Proteins/metabolism*
- In Situ Hybridization
- Nerve Tissue Proteins/genetics
- Nerve Tissue Proteins/metabolism*
- Spinal Cord/metabolism
- PubMed
- 10495280 Full text @ Mech. Dev.
Citation
Tan, J.T., Korzh, V., and Gong, Z.Y. (1999) Expression of a zebrafish iroquois homeobox gene, Ziro3, in the midline axial structures and central nervous system. Mechanisms of Development. 87(1-2):165-168.
Abstract
We describe a zebrafish gene, Ziro3, which is highly homologous to Xenopus and mouse iroquois3. Ziro3 expression starts during gastrulation in the dorsal axial mesoderm that develops into the notochord. Later, the expression is limited to the chordo-neural hinge in the tailbud. Ziro3 expression also occurs in the central nervous system (CNS), excluding the telencephalon. The level of Ziro3 expression differs in odd and even rhombomeres. In the midbrain-hindbrain boundary (MHB) and rhombomere 6, Ziro3 transcripts appear only after the formation of the cerebellum and otic vesicle, respectively.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping