PUBLICATION
Getting a-head of the organizer: anterior-posterior patterning of the forebrain
- Authors
- Brewster, R. and Dahmane, N.
- ID
- ZDB-PUB-990824-45
- Date
- 1999
- Source
- BioEssays : news and reviews in molecular, cellular and developmental biology 21(8): 631-636 (Review)
- Registered Authors
- Brewster, Rachel
- Keywords
- none
- MeSH Terms
-
- Animals
- Anura
- Body Patterning
- Chick Embryo
- Embryonic Induction
- Mice
- Prosencephalon/embryology*
- Signal Transduction
- Zebrafish
- PubMed
- 10440859 Full text @ Bioessays
Citation
Brewster, R. and Dahmane, N. (1999) Getting a-head of the organizer: anterior-posterior patterning of the forebrain. BioEssays : news and reviews in molecular, cellular and developmental biology. 21(8):631-636.
Abstract
The molecular mechanisms that drive the development of embryonic tissues are being uncovered rapidly. One such fascinating example is the development of the forebrain, the most anterior part of the nervous system. In this review, we will discuss the mechanisms that induce the formation of the forebrain in multiple vertebrate systems, placing emphasis on a recent article published by Grinblat et al.((1)) Using zebrafish as a model system, these authors combine elegant embryological manipulations with the use of early markers of the presumptive forebrain, to show that initial induction and patterning of this tissue occurs near the onset of gastrulation. In addition, their results confirm observations made in other systems that planar signals, those traveling in the plane of the ectoderm, are involved in forebrain induction and patterning.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping