ZFIN ID: ZDB-PUB-990616-3
Restricted expression of the receptor serine/threonine kinase BMPR-IB in zebrafish
Nikaido, M., Tada, M., and Ueno, N.
Date: 1999
Source: Mechanisms of Development   82(1-2): 219-222 (Journal)
Registered Authors: Nikaido, Masataka, Tada, Masazumi, Ueno, Naoto
Keywords: zebrafish; BMP; BMP receptor; somite; CNS
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Bone Morphogenetic Protein Receptors, Type I
  • Cloning, Molecular
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Enzymologic
  • Humans
  • In Situ Hybridization
  • Mesencephalon/embryology
  • Mesencephalon/enzymology
  • Molecular Sequence Data
  • Phylogeny
  • Protein Serine-Threonine Kinases/genetics*
  • Receptors, Growth Factor/genetics*
  • Somites/enzymology
  • Zebrafish/embryology*
  • Zebrafish/genetics*
PubMed: 10354489 Full text @ Mech. Dev.
Bone morphogenetic proteins (BMPs) comprise a rapidly expanding subclass of the transforming growth factor-beta superfamily. They are known to regulate a diverse range of developmental phenomena including cell differentiation, morphogenesis and apoptosis. In this study, we have isolated a zebrafish homolog of BMP type IB receptor (BMPR-IB) and examined the localization of the transcripts during embryogenesis. Whole-mount in situ hybridization analysis revealed that unlike other type I and type II receptors that mediate BMP signal, it is expressed in developing somite and in mid-hind brain region in a restricted manner.