|ZFIN ID: ZDB-PUB-990616-3|
Restricted expression of the receptor serine/threonine kinase BMPR-IB in zebrafish
Nikaido, M., Tada, M., and Ueno, N.
|Source:||Mechanisms of Development 82(1-2): 219-222 (Journal)|
|Registered Authors:||Nikaido, Masataka, Tada, Masazumi, Ueno, Naoto|
|Keywords:||zebrafish; BMP; BMP receptor; somite; CNS|
|PubMed:||10354489 Full text @ Mech. Dev.|
Nikaido, M., Tada, M., and Ueno, N. (1999) Restricted expression of the receptor serine/threonine kinase BMPR-IB in zebrafish. Mechanisms of Development. 82(1-2):219-222.
ABSTRACTBone morphogenetic proteins (BMPs) comprise a rapidly expanding subclass of the transforming growth factor-beta superfamily. They are known to regulate a diverse range of developmental phenomena including cell differentiation, morphogenesis and apoptosis. In this study, we have isolated a zebrafish homolog of BMP type IB receptor (BMPR-IB) and examined the localization of the transcripts during embryogenesis. Whole-mount in situ hybridization analysis revealed that unlike other type I and type II receptors that mediate BMP signal, it is expressed in developing somite and in mid-hind brain region in a restricted manner.