PUBLICATION
Holy Tolloido: Tolloid cleaves SOG/Chordin to free DPP/BMPs
- Authors
- Mullins, M.C.
- ID
- ZDB-PUB-990604-8
- Date
- 1998
- Source
- Trends in genetics : TIG 14(4): 127-129 (Review)
- Registered Authors
- Mullins, Mary C.
- Keywords
- none
- MeSH Terms
-
- Animals
- Bone Morphogenetic Proteins/genetics
- Bone Morphogenetic Proteins/metabolism*
- Drosophila/enzymology*
- Drosophila Proteins*
- Glycoproteins*
- Insect Proteins/genetics
- Insect Proteins/metabolism*
- Intercellular Signaling Peptides and Proteins*
- Metalloendopeptidases/metabolism*
- Morphogenesis
- Proteins/genetics
- Proteins/metabolism*
- Tolloid-Like Metalloproteinases
- Transforming Growth Factor beta/genetics
- Xenopus Proteins*
- PubMed
- 9594656 Full text @ Trends Genet.
Citation
Mullins, M.C. (1998) Holy Tolloido: Tolloid cleaves SOG/Chordin to free DPP/BMPs. Trends in genetics : TIG. 14(4):127-129.
Abstract
The molecular mechanism by which a group of zygotically acting genes identified almost 15 years ago1 establishes dorsal cell fates in Drosophila is just being elucidated. A similar mechanism has been found in the establishment of the dorsal–ventral axis in the vertebrate embryo. The key genes in these processes are TGF- molecules, Decapentaplegic (DPP) in flies and bone morphogenetic proteins (BMPs) in vertebrates. Conservation of genes in the DPP/BMP pathway in vertebrates and invertebrates strongly indicates that the basic mechanism establishing dorsal–ventral pattern formation has been conserved throughout evolution. Although both sets of genes establish non-neural ectodermal derivatives, the axes from which these cell types originate have opposite designations to each other: ventral in vertebrates is dorsal in invertebrates, and vice versa2. Here I discuss the mechanism recently identified by which the metalloprotease Tolloid in flies, frogs and zebrafish functions in a double inhibition mechanism to establish the graded activity of DPP/BMPs along the dorsal–ventral axis. To place the role of tolloid/Xolloid into context, I first review data on the function of other genes in the pathway.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping