PUBLICATION

Molecular mechanisms of vertebrate left–right development

Authors
Ramsdell, A.F. and Yost, H.J.
ID
ZDB-PUB-990604-7
Date
1998
Source
Trends in genetics : TIG   14(11): 459-465 (Review)
Registered Authors
Ramsdell, Ann F., Yost, H. Joseph
Keywords
none
MeSH Terms
  • Animals
  • Body Patterning/genetics*
  • Embryo, Nonmammalian
  • Functional Laterality/physiology*
  • Gene Expression Regulation, Developmental*
  • Humans
  • Mesoderm
  • Vertebrates/physiology*
  • Xenopus/embryology
PubMed
9825674 Full text @ Trends Genet.
Abstract
Patterning of all tissues and organs in the vertebrate embryo occurs along the dorsoventral (DV), anteroposterior (AP), and left-right (LR) body axes. Whereas significant progress has been made in identifying the processes underlying DV and AP patterning, relatively little is known about mechanisms guiding LR development. The significant incidence of human disease conditions associated with LR laterality defects, particularly those of the cardiovascular system, underscores the importance of understanding how LR asymmetries become established in the embryo. The focus of this review is on recently identified genes that are involved in generation of vertebrate LR asymmetry, and the proposed cellular and molecular mechanisms by which they might function in initiation, propagation and interpretation of LR patterning information.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping