Dual specificity of activin type II receptor ActRIIb in dorso-ventral patterning during zebrafish embryogenesis
- Nagaso, H., Suzuki, A., Tada, M., and Ueno, N.
- Development, growth & differentiation 41(2): 119-133 (Journal)
- Registered Authors
- Tada, Masazumi, Ueno, Naoto
- activin; activin type II receptor; bone morphogenetic protein; mesoderm induction; zebrafish
- MeSH Terms
- Activin Receptors, Type II
- Amino Acid Sequence
- Base Sequence
- Body Patterning/physiology*
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- Molecular Sequence Data
- RNA, Messenger/genetics
- Receptors, Growth Factor/genetics
- Receptors, Growth Factor/metabolism
- Receptors, Growth Factor/physiology*
- Sequence Homology, Amino Acid
- Signal Transduction
- 10223708 Full text @ Dev. Growth Diff.
Nagaso, H., Suzuki, A., Tada, M., and Ueno, N. (1999) Dual specificity of activin type II receptor ActRIIb in dorso-ventral patterning during zebrafish embryogenesis. Development, growth & differentiation. 41(2):119-133.
Members of the transforming growth factor-beta (TGF-beta) superfamily are thought to regulate specification of a variety of tissue types in early embryogenesis. These effects are mediated through a cell surface receptor complex, consisting of two classes of ser/thr kinase receptor, type I and type II. In the present study, cDNA encoding zebrafish activin type II receptors, ActRIIa and ActRIIb was cloned and characterized. Overexpression of ActRIIb in zebrafish embryos caused dorsalization of embryos, as observed in activin-overexpressing embryos. However, in blastula stage embryos, ActRIIb induced formation of both dorsal and ventro-lateral mesoderm. It has been suggested that these inducing signals from ActRIIb are mediated through each specific type I receptor, TARAM-A and BMPRIA, depending on activin and bone morphogenetic protein (BMP), respectively. In addition, it was shown that a kinase-deleted form of ActRIIb (dnActRIIb) suppressed both activin- and BMP-like signaling pathways. These results suggest that ActRIIb at least has dual roles in both activin and BMP signaling pathways during zebrafish embryogenesis.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes