PUBLICATION
A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates
- Authors
- Meng, A., Moore, B., Tang, H., Yuan, B., and Lin, S.
- ID
- ZDB-PUB-990428-2
- Date
- 1999
- Source
- Development (Cambridge, England) 126: 1259-1268 (Journal)
- Registered Authors
- Lin, Shuo, Meng, Anming, Yuan, Ben
- Keywords
- zebrafish; terra; somitogenesis; transcription factor; secreted signal
- MeSH Terms
-
- Mice
- Protein Biosynthesis
- Humans
- Zinc Fingers
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Proteins/biosynthesis
- Transforming Growth Factor beta*
- Hedgehog Proteins
- DNA-Binding Proteins/biosynthesis
- DNA-Binding Proteins/genetics*
- Molecular Sequence Data
- Apoptosis
- Drosophila Proteins*
- Insect Proteins/genetics
- Trans-Activators*
- Conserved Sequence
- Gene Expression Regulation, Developmental*
- Drosophila/genetics
- Zebrafish/embryology
- Amino Acid Sequence
- Transcription Factors*
- Zebrafish Proteins*
- Sequence Homology, Amino Acid
- Vertebrates/embryology*
- Somites*
- Animals
- Up-Regulation
- PubMed
- 10021344 Full text @ Development
Citation
Meng, A., Moore, B., Tang, H., Yuan, B., and Lin, S. (1999) A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development (Cambridge, England). 126:1259-1268.
Abstract
The Drosophila doublesex (dsx) gene encodes a transcription factor that mediates sex determination. We describe the characterization of a novel zebrafish zinc-finger gene, terra, which contains a DNA binding domain similar to that of the Drosophila dsx gene. However, unlike dsx, terra is transiently expressed in the presomitic mesoderm and newly formed somites. Expression of terra in presomitic mesoderm is restricted to cells that lack expression of MyoD. In vivo, terra expression is reduced by hedgehog but enhanced by BMP signals. Overexpression of terra induces rapid apoptosis both in vitro and in vivo, suggesting that a tight regulation of terra expression is required during embryogenesis. Terra has both human and mouse homologs and is specifically expressed in mouse somites. Taken together, our findings suggest that terra is a highly conserved protein that plays specific roles in early somitogenesis of vertebrates
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping