ZFIN ID: ZDB-PUB-990427-17
Expression of zkrml2, a homologue of the Krml1/val segmentation gene, during embryonic patterning of the zebrafish
Schvarzstein, M., Kirn, A., Haffter, P., and Cordes, S.P.
Date: 1999
Source: Mechanisms of Development   80(2): 223-226 (Journal)
Registered Authors: Haffter, Pascal
Keywords: kreisler; valentino; basic domain leucine zipper; Maf protein; somitogenesis; myogenesis; zebrafish
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Avian Proteins*
  • Chromosome Mapping
  • DNA-Binding Proteins/biosynthesis
  • DNA-Binding Proteins/genetics*
  • Embryo, Nonmammalian/metabolism
  • Embryo, Nonmammalian/ultrastructure
  • Female
  • Gene Expression Regulation, Developmental*
  • Genes*
  • Leucine Zippers/genetics
  • Maf Transcription Factors
  • MafB Transcription Factor
  • Male
  • Mesencephalon/embryology
  • Mesencephalon/metabolism
  • Mice
  • Molecular Sequence Data
  • Morphogenesis/genetics
  • Mutagenesis
  • Nerve Tissue Proteins/biosynthesis
  • Nerve Tissue Proteins/genetics
  • Neurons/metabolism
  • Oncogene Proteins*
  • Organ Specificity
  • Proto-Oncogene Proteins/genetics
  • Proto-Oncogene Proteins c-maf
  • Rhombencephalon/embryology
  • Rhombencephalon/metabolism
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Somites/metabolism*
  • Species Specificity
  • Transcription Factors/biosynthesis
  • Transcription Factors/genetics*
  • Zebrafish/embryology
  • Zebrafish/genetics*
  • Zebrafish Proteins*
PubMed: 10072793 Full text @ Mech. Dev.
We have identified Zkrml2, a novel homologue of the segmentation gene Krml/val in zebrafish (Danio rerio). Zkrml2 shows 72% and 92% identity in its basic leucine zipper domain with mouse Krml1 and zebrafish val, respectively. Zkrml2 is expressed coincident with MyoD throughout the somites starting at the three somite stage, becomes restricted to the dermomyotome, and subsequently disappears. Transient expression is also detected in the reticulospinal and oculomotor neurons. Zkrml2 maps to the Oregon linkage group 11 (Boston Linkage group 14) with no mapped zebrafish mutations nearby.