Cone contributions to the photopic spectral sensitivity of the zebrafish ERG
- Hughes, A., Saszik, S., Bilotta, J., DeMarco, Jr., P.J., and Patterson II, W.F.
- Visual neuroscience 15: 1029-1037 (Journal)
- Registered Authors
- Bilotta, Joe
- Danio rerio; electroretinogram; color opponency; ultraviolet cones
- MeSH Terms
- Adaptation, Physiological/physiology
- Color Perception/physiology*
- Models, Biological
- Retinal Cone Photoreceptor Cells/physiology*
- 9839967 Full text @ Vis. Neurosci.
Hughes, A., Saszik, S., Bilotta, J., DeMarco, Jr., P.J., and Patterson II, W.F. (1998) Cone contributions to the photopic spectral sensitivity of the zebrafish ERG. Visual neuroscience. 15:1029-1037.
Microspectrophotometry studies show that zebrafish (Danio rerio) possess four cone photopigments. The purpose of this study was to determine the cone contributions to the zebrafish photopic increment threshold spectral-sensitivity function. Electroretinogram (ERG) b-wave responses to monochromatic lights presented on a broadband or chromatic background were obtained. It was found that under the broadband background condition, the zebrafish spectral-sensitivity function showed several peaks that were narrower in sensitivity compared to the cone spectra. The spectral-sensitivity function was modeled with L - M and M - S opponent interactions and nonopponent S- and U-cone mechanisms. Using chromatic adaptation designed to suppress the contribution of the S-cones, a strong U-cone contribution to the spectral-sensitivity function was revealed, and the contributions of the S-cones to the M - S mechanism were reduced. These results show that the b-wave component of the ERG receives input from all four cone types and appears to reflect color opponent mechanisms. Thus, zebrafish may possess the fundamental properties necessary for color vision.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes