PUBLICATION
Functional analysis of zebrafish Islet-1 protein family
- Authors
- Kikuchi, Y., Tokumoto, M., Hotta, Y., Uyemura, K., and Okamoto, H.
- ID
- ZDB-PUB-981110-4
- Date
- 1996
- Source
- Neuroscience research 25 sup. 2: 116 (Abstract)
- Registered Authors
- Kikuchi, Yutaka, Okamoto, Hitoshi, Uyemura, Osamu
- Keywords
- none
- MeSH Terms
- none
- PubMed
- none Full text @ Neurosci. Res.
Citation
Kikuchi, Y., Tokumoto, M., Hotta, Y., Uyemura, K., and Okamoto, H. (1996) Functional analysis of zebrafish Islet-1 protein family. Neuroscience research. 25 sup. 2:116.
Abstract
LIM/homeobox transcription factors play important roles in cell fate determination during development in both vertebrates and invertebrates. We have cloned cDNAs for these factors in zebrafish (Islet-1, -2, -3). Functional studies of other LIM/homeobox proteins have suggested that LIM domains act as interfaces for binding with other proteins. We reasoned that the formation of a functional complex may be prevented by the ectopic overexpression of the LIM domains without a homeobox. Ectopic expression of the LIM domains in Islet-3 caused the defective development in the tissue where Islet-3 was normally expressed.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping