ZFIN ID: ZDB-PUB-980722-20
Physiological genomics: mutant screens in zebrafish
Warren, K.S. and Fishman, M.C.
Date: 1998
Source: The American journal of physiology   275: H1-H7 (Journal)
Registered Authors: Fishman, Mark C., Warren, Kerri S.
Keywords: mutagenesis; embryonic physiology; embryonic cardiovasculature; vertebrate genetic screen
MeSH Terms:
  • Animals
  • Crosses, Genetic
  • Embryo, Nonmammalian/physiology
  • Female
  • Fetal Heart/physiology*
  • Heart Conduction System/embryology
  • Heart Rate, Fetal
  • Male
  • Mutagenesis
  • Mutation*
  • Myocardial Contraction
  • Pregnancy
  • Zebrafish/embryology*
  • Zebrafish/genetics*
PubMed: 9688889
Large-scale mutagenesis screens have proved essential in the search for genes that are important to development in the fly, worm, and yeast. Here we present the power of large-scale screening in a vertebrate, the zebrafish Danio rerio, and propose the use of this genetic system to address fundamental questions of vertebrate developmental physiology. As an example, we focus on zebrafish mutations that reveal single genes essential for normal development of the cardiovascular system. These single gene mutations disrupt specific aspects of rate, rhythm, conduction, or contractility of the developing heart.