PUBLICATION
Physiological genomics: mutant screens in zebrafish
- Authors
- Warren, K.S. and Fishman, M.C.
- ID
- ZDB-PUB-980722-20
- Date
- 1998
- Source
- The American journal of physiology 275: H1-H7 (Journal)
- Registered Authors
- Fishman, Mark C., Warren, Kerri S.
- Keywords
- mutagenesis; embryonic physiology; embryonic cardiovasculature; vertebrate genetic screen
- MeSH Terms
-
- Animals
- Crosses, Genetic
- Embryo, Nonmammalian/physiology
- Female
- Fetal Heart/physiology*
- Heart Conduction System/embryology
- Heart Rate, Fetal
- Male
- Mutagenesis
- Mutation*
- Myocardial Contraction
- Pregnancy
- Zebrafish/embryology*
- Zebrafish/genetics*
- PubMed
- 9688889 Full text @ Am. J. Physiol.
Citation
Warren, K.S. and Fishman, M.C. (1998) Physiological genomics: mutant screens in zebrafish. The American journal of physiology. 275:H1-H7.
Abstract
Large-scale mutagenesis screens have proved essential in the search for genes that are important to development in the fly, worm, and yeast. Here we present the power of large-scale screening in a vertebrate, the zebrafish Danio rerio, and propose the use of this genetic system to address fundamental questions of vertebrate developmental physiology. As an example, we focus on zebrafish mutations that reveal single genes essential for normal development of the cardiovascular system. These single gene mutations disrupt specific aspects of rate, rhythm, conduction, or contractility of the developing heart.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping