PUBLICATION
SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish
- Authors
- Liao, E.C., Paw, B.H., Oates, A.C., Pratt, S.J., Postlethwait, J.H., and Zon, L.I.
- ID
- ZDB-PUB-980415-5
- Date
- 1998
- Source
- Genes & Development 12: 621-626 (Journal)
- Registered Authors
- Liao, Eric, Oates, Andrew, Paw, Barry, Postlethwait, John H., Pratt, Stephen J., Zon, Leonard I.
- Keywords
- clo; zebrafish; hematopoiesis; vasculogenesis
- MeSH Terms
-
- Amino Acid Sequence
- Zebrafish/embryology*
- Zebrafish/genetics*
- Embryo, Nonmammalian
- Endothelium, Vascular/embryology*
- Transcription Factors*
- Zebrafish Proteins*
- Molecular Sequence Data
- Proto-Oncogene Proteins*
- Chromosome Mapping
- Basic Helix-Loop-Helix Transcription Factors
- Gene Expression Regulation, Developmental
- Animals
- Hematopoietic Stem Cells/physiology*
- Conserved Sequence
- DNA-Binding Proteins/genetics*
- DNA-Binding Proteins/metabolism
- Mutation
- PubMed
- 9499398 Full text @ Genes & Dev.
Citation
Liao, E.C., Paw, B.H., Oates, A.C., Pratt, S.J., Postlethwait, J.H., and Zon, L.I. (1998) SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes & Development. 12:621-626.
Abstract
SCL/Tal-1 is a transcription factor necessary for hematopoietic stem cell differentiation. Although SCL is also expressed in endothelial and neural progenitors, SCL function in these cells remains unknown. In the zebrafish mutant cloche (clo), SCL expression is nearly abolished in hematopoietic and vascular tissues. Correspondingly, it was shown previously that clo fails to differentiate blood and angioblasts. Genetic analysis demonstrates that the clo mutation is not linked to the SCL locus. Forced expression of SCL in clo embryos rescues the blood and vascular defects, suggesting that SCL acts downstream of clo to specify hematopoietic and vascular differentiation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping