PUBLICATION
Zebrafish TrkC1 and TrkC2 receptors define two different cell populations in the nervous system during the period of axonogenesis
- Authors
- Martin, S.C., Sandell, J.H., and Heinrich, G.
- ID
- ZDB-PUB-980415-12
- Date
- 1998
- Source
- Developmental Biology 195: 114-130 (Journal)
- Registered Authors
- Heinrich, Gerhard, Martin, Stella C., Sandell, Julie H.
- Keywords
- neurotrophin receptors; development; Rohon-Beard neurons; cranial ganglia; in situ hybridization
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Axons/physiology*
- Gene Expression Regulation, Developmental/physiology*
- Molecular Sequence Data
- Morphogenesis
- Nervous System/cytology
- Nervous System/embryology*
- Neurons/chemistry
- Organ Specificity
- RNA, Messenger/analysis
- Receptor Protein-Tyrosine Kinases/genetics*
- Receptor, trkC
- Receptors, Nerve Growth Factor/genetics*
- Sequence Deletion
- Sequence Homology, Amino Acid
- Zebrafish
- PubMed
- 9520329 Full text @ Dev. Biol.
Citation
Martin, S.C., Sandell, J.H., and Heinrich, G. (1998) Zebrafish TrkC1 and TrkC2 receptors define two different cell populations in the nervous system during the period of axonogenesis. Developmental Biology. 195:114-130.
Abstract
We identified previously five distinct trk genes in the zebrafish. The structures of two of these, TrkC1 and TrkC2, are most similar to mammalian TrkC. Detailed sequence comparisons reported here indicate that although the similarities to TrkC are greatest in those regions of the extracellular domain implicated in ligand binding, the two sequences also differ significantly in these regions. Whole- mount in situ hybridization experiments in the early embryo revealed full-length trkC1 but no trkC2 transcripts in the cranial ganglia and in a subset of Rohon-Beard neurons. At the same time, full-length trkC2 but no trkC1 transcripts were detected laterally in the spinal cord, in the caudal hindbrain, in reticulospinal neurons of rhombomeres 4, 5, and 6, and in the midbrain. Both types of transcripts were expressed in clusters of cells in the dorsal telencephalon and the nucleus of the tract of the postoptic commissure. These results suggest distinct functions of trkC1 and trkC2 in nervous system development. The expression patterns define two different neuronal populations in the zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping