PUBLICATION
Neurotrophin-7: a novel member of the neurotrophin family from the zebrafish
- Authors
- Nilsson, A.-S., Fainzilber, M., Falick, P., and Ibanez, C.F.
- ID
- ZDB-PUB-980415-10
- Date
- 1998
- Source
- FEBS letters 424: 285-290 (Journal)
- Registered Authors
- Keywords
- brain-derived neurotrophic factor; evolution; neurotrophic factor; nerve growth factor; p75; receptor tyrosine kinase
- MeSH Terms
-
- Animals
- Humans
- Rats
- Amino Acid Sequence
- COS Cells
- Receptor, Nerve Growth Factor
- Molecular Sequence Data
- Zebrafish Proteins*
- Base Sequence
- Phylogeny*
- Polymerase Chain Reaction
- Recombinant Proteins/genetics
- Recombinant Proteins/metabolism
- Sequence Homology, Amino Acid
- Receptors, Nerve Growth Factor/metabolism
- Culture Media, Conditioned
- Nerve Growth Factors/genetics*
- Nerve Growth Factors/metabolism*
- Zebrafish/genetics*
- PubMed
- 9580190 Full text @ FEBS Lett.
Citation
Nilsson, A.-S., Fainzilber, M., Falick, P., and Ibanez, C.F. (1998) Neurotrophin-7: a novel member of the neurotrophin family from the zebrafish. FEBS letters. 424:285-290.
Abstract
A novel member of the neurotrophin family, zebrafish neurotrophin-7 (zNT-7), was isolated from the zebrafish Danio rerio. The amino acid sequence of zNT-7 is more closely related to that of fish nerve growth factor (NGF) and neurotrophin-6 (NT-6) than to that of any other neurotrophin. zNT-7 is, however, equally related to fish NGF and NT-6 (65% and 63% amino acid sequence identity, respectively) indicating that it represents a distinct neurotrophin sequence. zNT-7 contains a 15 amino acid residue insertion in a beta-turn region in the middle of the mature protein. Recombinant zNT-7 was able to bind to the human p75 neurotrophin receptor and to induce tyrosine phosphorylation of the rat TrkA receptor tyrosine kinase, albeit less efficiently than rat NGF. zNT-7 did not interact with rat TrkB or TrkC, indicating a similar receptor specificity as NGF. We propose that a diversification of the NGF subfamily in the neurotrophin evolutionary tree occurred during the evolution of teleost fishes which resulted in the appearance of several additional members, such as zNT-7 and NT-6, structurally and functionally related to NGF.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping