PUBLICATION
Cloning and characterization of two isoforms of the zebrafish thyrotroph embryonic factor (tef-alpha and tef-beta)
- Authors
- Xu, X.Z., Liu, L.H., Wong, K.C.Y., and Ge, R.W.
- ID
- ZDB-PUB-980123-6
- Date
- 1998
- Source
- Biochim. Biophys. Acta Gene Struct. Exp. 1395: 13-20 (Journal)
- Registered Authors
- Liu, Lihui
- Keywords
- TEF; PAR subfamily; bZIP transcription factor; gene regulation; zebrafish
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Basic-Leucine Zipper Transcription Factors
- Cloning, Molecular
- Conserved Sequence/genetics
- Gene Expression Regulation, Developmental/physiology*
- Molecular Sequence Data
- Organ Specificity
- RNA, Messenger/analysis
- Sequence Analysis, DNA
- Sequence Homology, Amino Acid
- Transcription Factors/genetics*
- Zebrafish/genetics*
- Zebrafish Proteins*
- PubMed
- 9434145 Full text @ Biochim. Biophys. Acta Gene Struct. Exp.
Citation
Xu, X.Z., Liu, L.H., Wong, K.C.Y., and Ge, R.W. (1998) Cloning and characterization of two isoforms of the zebrafish thyrotroph embryonic factor (tef-alpha and tef-beta). Biochim. Biophys. Acta Gene Struct. Exp.. 1395:13-20.
Abstract
We have cloned and sequenced two cDNAs representing two isoforms of the zebrafish thyrotroph embryonic factor (TEF) gene products (tef alpha and beta), a member of the PAR subfamily of bZIP transcription factors. The two isoforms encode two potential proteins of 300 and 293 amino acids respectively. Sequence comparison analysis indicate that the zebrafish tefs show high homology to PAR family of transcription factors of other species in the PAR domain, DNA binding domain and leucine zipper domain. Expression analysis by Northern blot and RT-PCR indicates that tef alpha and tefbeta are expressed in adult fish and throughout the zebrafish embryonic development. In addition, the two tefs are expressed in some adult tissues, but not others.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping