PUBLICATION

Cloning of the swelling-dependent chloride channel lCln homologue from zebrafish

Authors
Schmarda, A., Nagl, U.O., Gschwentner, M., Fürst, J., Hofer, S., Deetjen, P., and Paulmichl, M.
ID
ZDB-PUB-971114-4
Date
1997
Source
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology   7(5): 298-302 (Journal)
Registered Authors
Paulmichl, M.
Keywords
l-Cln; volume regulation; regulatory volume decrease; zebrafish; RVD
MeSH Terms
none
PubMed
none
Abstract
Using expression cloning techniques, a protein was isolated which gave rise to an outwardly rectifying chloride current after expression in Xenopus laevis oocytes [Paulmichl et al., Nature 1992;356:238-241]. We termed this protein ICln and found it to be crucial for the regulatory volume decrease after swelling cells in hypotonic medium. Here we describe the cloning of the zebra fish homologue to ICln and, in addition, specify the epitope recognized by the antibodies we raised in rabbits against a synthetic peptide comprised by the C-terminal 24 amino acids of ICln
Genes / Markers
Figures
No images available
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Schmarda, A., Nagl, U.O., Gschwentner, M., Fürst, J., Hofer, S., Deetjen, P., and Paulmichl, M. (1997) Cloning of the swelling-dependent chloride channel lCln homologue from zebrafish. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 7(5):298-302.