PUBLICATION
Expression of contact, a new zebrafish DVR member, marks mesenchymal cell lineages in the developing pectoral fins and head and is regulated by retinoic acid
- Authors
- Bruneau, S., Mourrain, P., and Rosa, F.M.
- ID
- ZDB-PUB-970918-2
- Date
- 1997
- Source
- Mechanisms of Development 65(1-2): 163-173 (Journal)
- Registered Authors
- Bruneau, Sylvia, Rosa, Frederic
- Keywords
- TGF-beta; zebrafish; pectoral fins; retinoic acid; pharyngeal arches
- MeSH Terms
-
- Cell Lineage
- Zebrafish Proteins*
- Growth Differentiation Factor 5
- Proteins/genetics*
- Sequence Alignment
- Amino Acid Sequence
- Keratolytic Agents/pharmacology*
- Head/embryology
- Transforming Growth Factor beta/genetics*
- Zebrafish/embryology*
- Mice
- Animals
- Mesoderm
- Tretinoin/pharmacology*
- Molecular Sequence Data
- Gene Expression Regulation, Developmental/drug effects*
- Humans
- PubMed
- 9256353 Full text @ Mech. Dev.
Citation
Bruneau, S., Mourrain, P., and Rosa, F.M. (1997) Expression of contact, a new zebrafish DVR member, marks mesenchymal cell lineages in the developing pectoral fins and head and is regulated by retinoic acid. Mechanisms of Development. 65(1-2):163-173.
Abstract
Contact, a new zebrafish transforming growth factor-beta (TGF-beta) member is most closely related to mouse GDF5 and to human CDMP-1 responsible, when mutated, for limb brachypodism phenotype and Hunter-Thompson syndrome, respectively. Contact exhibits a dynamic spatial expression pattern in the pharyngeal arches and the pectoral fin buds that much prefigures cartilage formation. Within the fin buds, contact expression is detected in the proximal mesenchyme from which the endoskeleton will develop. Exogeneously applied retinoic acid (RA) induces duplication of the pectoral fin rudiment in zebrafish embryos as well as contact expression along the proximal margin of the fin mesenchyme showing that both endoskeleton and exoskeleton can be duplicated.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping