PUBLICATION
A novel zebrafish gene expressed specifically in the photoreceptor cells of the retina
- Authors
- Chang, H. and Gilbert, W.
- ID
- ZDB-PUB-970903-7
- Date
- 1997
- Source
- Biochemical and Biophysical Research Communications 237(1): 84-89 (Journal)
- Registered Authors
- Chang, H., Gilbert, Walter
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Bacterial Proteins/chemistry
- Basic Helix-Loop-Helix Transcription Factors
- Blotting, Western
- Cloning, Molecular
- Escherichia coli/genetics
- Escherichia coli Proteins*
- Eye Proteins/biosynthesis*
- Eye Proteins/chemistry*
- Homeodomain Proteins*
- Humans
- Immunohistochemistry
- Mitochondrial Proteins*
- Molecular Sequence Data
- Photoreceptor Cells/metabolism*
- Proteins/chemistry
- RNA, Messenger/biosynthesis
- Recombinant Proteins/biosynthesis
- Recombinant Proteins/chemistry
- Recombinant Proteins/immunology
- Sequence Alignment
- Sequence Homology, Amino Acid
- Transcription, Genetic*
- Zebrafish/genetics*
- Zebrafish Proteins*
- PubMed
- 9266834 Full text @ Biochem. Biophys. Res. Commun.
Citation
Chang, H. and Gilbert, W. (1997) A novel zebrafish gene expressed specifically in the photoreceptor cells of the retina. Biochemical and Biophysical Research Communications. 237(1):84-89.
Abstract
We have identified and characterized a novel protein from adult zebrafish retina, which we named ES1. Database search revealed that the ES1 gene has significant similarity to two genes with unknown functions: the Escherichia coli sigma cross-reacting protein 27a (scrp27a) and the human KNP-I/GT335. In situ hybridization and immunohistochemistry experiments showed that both ES1 mRNA and protein are expressed specifically in adult photoreceptor cells. ES1 seems to be a cytoplasmic protein. An ES1-like antigen was also detected in photoreceptor cells of goldfish with anti-ES1 antibodies. The retina specific expression and the evolutionary conservation suggest that ES1 protein may be important for maintaining normal retina structure and function.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping