PUBLICATION
Distribution of Pax6 protein during eye development suggests discrete roles in proliferative and differentiated visual cells
- Authors
- Macdonald, R. and Wilson, S.W.
- ID
- ZDB-PUB-970327-6
- Date
- 1997
- Source
- Development genes and evolution 206: 363-369 (Journal)
- Registered Authors
- Macdonald, Rachel, Wilson, Steve
- Keywords
- zebrafish, paired box, pax6, eye development, neuronal differentiation
- MeSH Terms
- none
- PubMed
- none
Citation
Macdonald, R. and Wilson, S.W. (1997) Distribution of Pax6 protein during eye development suggests discrete roles in proliferative and differentiated visual cells. Development genes and evolution. 206:363-369.
Abstract
Although Pax6 is required during eye development
in rodents and humans, little is known about the precise
role of the protein in this process. To aid in the interpretation
of functional studies, we have determined the
precise spatial and temporal distributions of the Pax6 protein
in the eye. We find that Pax6 is initially distributed
contiguously throughout a large domain of the anterior
neural plate of zebrafish, including the presumptive eye
fields and the dorsal diencephalon. After evagination of
the optic vesicle, Pax6 becomes restricted to all proliferating
cells of the pigment epithelial and neural layers of the
retina. Pax6 is downregulated in most cells concomitant
with differentiation. However, it remains present in several
mature cell types of the eye including amacrine cells and
the lens and corneal epithelia. This expression is conserved
across diverse vertebrate species and suggests that
Pax6 has additional conserved functions in the mature eye.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping