Genetic analysis of axon guidance and mapping in the zebrafish
- Karlstrom, R.O., Trowe, T., and Bonhoeffer, F.
- Trends in neurosciences 20(1): 3-8 (Review)
- Registered Authors
- Bonhoeffer, Friedrich, Karlstrom, Rolf, Trowe, Torsten
- MeSH Terms
- Nervous System/cytology
- Nervous System/embryology*
- 9004410 Full text @ Trends Neurosci.
Karlstrom, R.O., Trowe, T., and Bonhoeffer, F. (1997) Genetic analysis of axon guidance and mapping in the zebrafish. Trends in neurosciences. 20(1):3-8.
Systematic genetic screens have been powerful tools in identifying genes responsible for axon guidance in fruitflies and nematodes. This approach has now been extended to the study of axon guidance and the formation of topographic neuronal connections in the vertebrate brain. A systematic genetic screen was used to identify genes responsible for precise axon pathfinding and targeting in the retinotectal system of the zebrafish (Danio rerio). Over 30 genes were found that affect either: (1) retinal axon pathfinding to the contralateral tectal lobe; or (2) the topographic connection between the eye and the tectum. The zebrafish retinotectal mutants represent a new resource for the study of axon guidance in the vertebrate brain.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes