PUBLICATION
Pathway selection by growth cones in the zebrafish central nervous system
- Authors
- Kuwada, J.Y.
- ID
- ZDB-PUB-961101-38
- Date
- 1993
- Source
- Perspectives on developmental neurobiology 1: 195-203 (Review)
- Registered Authors
- Kuwada, John
- Keywords
- none
- MeSH Terms
-
- Animals
- Axons/physiology
- Axons/ultrastructure
- Brain Tissue Transplantation
- Cell Differentiation
- Central Nervous System/cytology
- Central Nervous System/embryology*
- Chemotaxis
- Embryo, Nonmammalian/physiology
- Embryo, Nonmammalian/ultrastructure
- Embryonic Induction
- Embryonic and Fetal Development
- Morphogenesis/genetics
- Mutation
- Neurites/physiology*
- Neurons/transplantation
- Phenotype
- Spinal Cord/cytology
- Spinal Cord/embryology
- Transplantation, Heterotopic
- Zebrafish/embryology*
- Zebrafish/genetics
- PubMed
- 8087544
Citation
Kuwada, J.Y. (1993) Pathway selection by growth cones in the zebrafish central nervous system. Perspectives on developmental neurobiology. 1:195-203.
Abstract
The accessibility and simplicity of the zebrafish embryo have led to a detailed characterization of pathfinding by identifiable growth cones in both the spinal cord and brain. These growth cones follow precise, cell-specific pathways to their targets. Analyses of pathfinding in mutant embryos and wild-type embryos following laser ablation or transplantation of specific cells demonstrate that growth cones accomplish this by interacting with specific cellular cues in their environment, many of which are likely to be redundant. These experiments suggest that a combination of separate pathway and directionality cues are required for pathfinding by growth cones. Growth cones distinguish different pathways by sensing specific pathway cues and know what direction they should extend on a pathway by sensing widely distributed directionality cues.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping