PUBLICATION

Asynchronous onset of odorant receptor expression in the developing zebrafish olfactory system

Authors
Barth, A.L., Justice, N.J., and Ngai, J.
ID
ZDB-PUB-961014-75
Date
1996
Source
Neuron   16: 23-34 (Journal)
Registered Authors
Barth, Alison, Ngai, John
Keywords
none
MeSH Terms
  • Olfactory Receptor Neurons/metabolism
  • Morphogenesis
  • Molecular Sequence Data
  • Olfactory Pathways/embryology*
  • Olfactory Pathways/growth & development
  • Binding, Competitive
  • Amino Acid Sequence
  • In Situ Hybridization
  • Polymerase Chain Reaction
  • Receptors, Odorant/biosynthesis*
  • Receptors, Odorant/classification
  • Receptors, Odorant/genetics
  • Multigene Family
  • Age Factors
  • Epithelium/embryology
  • Epithelium/metabolism
  • Zebrafish/embryology*
  • Zebrafish/growth & development
  • Animals
  • Olfactory Mucosa/embryology
  • Olfactory Mucosa/metabolism
  • Gene Expression Regulation, Developmental*
  • Transcription, Genetic
(all 23)
PubMed
8562087 Full text @ Neuron
Abstract
The functional identity of an olfactory neuron is determined in large part by the odorant receptors it expresses. As an approach toward understanding the events that underlie the specification of olfactory neurons, we have examined the patterns of odorant receptor gene expression in the developing zebrafish. Surprisingly, we find that the onset of specific odorant receptor expression occurs asynchronously in the developing olfactory placode. Our results suggest that odorant receptor expression is not strictly stochastic, but rather is governed by temporally regulated cues during development. Moreover, by restricting the number of receptor genes competent for transcription at different times of development, temporal waves of expression may provide a mechanism for simplifying the regulation of the large odorant receptor gene family.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Barth, A.L., Justice, N.J., and Ngai, J. (1996) Asynchronous onset of odorant receptor expression in the developing zebrafish olfactory system. Neuron. 16:23-34.