PUBLICATION
Retinoic acid is necessary for development of the ventral retina in zebrafish
- Authors
- Marsh-Armstrong, N., McCaffery, P., Gilbert, W., Dowling, J.E., and Dräger, U.C.
- ID
- ZDB-PUB-961014-734
- Date
- 1994
- Source
- Proceedings of the National Academy of Sciences of the United States of America 91: 7286-7290 (Journal)
- Registered Authors
- Dowling, John E., Dräger, Ursula, Gilbert, Walter, McCaffery, Peter J.
- Keywords
- none
- MeSH Terms
-
- Animals
- Morphogenesis
- Retina/embryology*
- Retina/metabolism
- Tretinoin/metabolism*
- Zebrafish
- PubMed
- 8041782 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Marsh-Armstrong, N., McCaffery, P., Gilbert, W., Dowling, J.E., and Dräger, U.C. (1994) Retinoic acid is necessary for development of the ventral retina in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 91:7286-7290.
Abstract
In the embryonic zebrafish retina, as in other vertebrates, retinoic acid is synthesized from retinaldehyde by two different dehydrogenases, one localized dorsally, the other primarily ventrally. Early in eye development only the ventral enzyme is present. Citral competitively inhibits the ventral enzyme in vitro and decreases the production of retinoic acid in the ventral retina in vivo. Treatment of neurula-stage zebrafish embryos with citral during the formation of the eye primordia results in eyes lacking a ventral retina. This defect can be partially rescued by retinoic acid. The results demonstrate that synthesis of retinoic acid can be selectively inhibited in vivo and suggest that retinoic acid is necessary for the proper development of the ventral retina.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping