PUBLICATION
Cloning of fish zinc-finger genes related to Krox-20 and Krox-24
- Authors
- Lanfear, J., Jowett, T., and Holland, P.W.H.
- ID
- ZDB-PUB-961014-675
- Date
- 1991
- Source
- Biochemical and Biophysical Research Communications 179: 1220-1224 (Journal)
- Registered Authors
- Jowett, Trevor
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Southern
- Cell Line
- DNA/genetics*
- DNA/isolation & purification
- Fishes/genetics*
- Genes*
- Liver/physiology
- Mice
- Mice, Inbred DBA/genetics
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Poecilia/genetics
- Polymerase Chain Reaction
- Sequence Homology, Nucleic Acid
- Zebrafish/genetics
- Zinc Fingers/genetics*
- PubMed
- 1930167 Full text @ Biochem. Biophys. Res. Commun.
Citation
Lanfear, J., Jowett, T., and Holland, P.W.H. (1991) Cloning of fish zinc-finger genes related to Krox-20 and Krox-24. Biochemical and Biophysical Research Communications. 179:1220-1224.
Abstract
Southern hybridization suggests that the zebrafish genome contains multiple zinc-finger genes related to the putative mouse developmental genes, Krox-20 and Krox-24. The polymerase chain reaction was employed to amplify and clone the zinc-finger regions of genes related to Krox-20, from two fish species and, for comparison, mouse, hamster and fox. DNA sequence analyses suggest that the genes cloned include the guppy homologue of Krox-20 and the zebrafish homologue of Krox-24, and that these genes diverged prior to the separation of the lineages leading to teleosts and to mammals.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping