PUBLICATION
Cell cycles and clonal strings during formation of the zebrafish central nervous system
- Authors
- Kimmel, C.B., Warga, R.M., and Kane, D.A.
- ID
- ZDB-PUB-961014-606
- Date
- 1994
- Source
- Development (Cambridge, England) 120: 265-276 (Journal)
- Registered Authors
- Kane, Donald A., Kimmel, Charles B., Warga, Rachel M.
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Cycle/physiology*
- Central Nervous System/cytology
- Central Nervous System/embryology*
- Clone Cells
- DNA-Binding Proteins/genetics*
- Embryonic Induction/physiology*
- Gastrula/physiology*
- Homeodomain Proteins*
- Microscopy, Electron
- Morphogenesis/physiology
- Zebrafish/embryology*
- PubMed
- 8149908 Full text @ Development
Citation
Kimmel, C.B., Warga, R.M., and Kane, D.A. (1994) Cell cycles and clonal strings during formation of the zebrafish central nervous system. Development (Cambridge, England). 120:265-276.
Abstract
Cell lineage analysis of central nervous system progenitors during gastrulation and early segmentation in the zebrafish reveals consistent coupling of specific morphogenetic behaviors with particular cell cycles. Cells in single clones divide very synchronously. Cell divisions become progressively oriented, and act synergistically with oriented intercalations during the interphases of zygotic cell cycles 15 and 16 to extend a single lineage into a long, discontinuous string of cells aligned with the nascent embryonic axis. Dorsalwards convergence brings the string to the midline and, once there, cells enter division 16. This division, or sometimes the next one, and the following cell movement reorient to separate siblings across the midline. This change converts the single string into a bilateral pair of strings, one forming a part of each side of the neural tube. The stereotyped cellular behaviors appear to account for the previously reported clonal restriction in cell fate and to underlie morphogenesis of a midline organ of proper length and bilateral shape. Regulation of cellular morphogenesis could be cell-cycle dependent.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping