PUBLICATION
Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of ß-catenin
- Authors
- Kelly, G.M., Erezyilmaz, D.F., and Moon, R.T.
- ID
- ZDB-PUB-961014-543
- Date
- 1995
- Source
- Mechanisms of Development 53(2): 261-273 (Journal)
- Registered Authors
- Kelly, Greg, Moon, Randall T.
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Cytoskeletal Proteins/biosynthesis*
- Embryo, Nonmammalian/metabolism
- Gene Expression Regulation, Developmental/physiology*
- Molecular Sequence Data
- Multigene Family
- Phenotype
- Protein Biosynthesis*
- Proteins*
- Trans-Activators*
- Wnt Proteins
- Xenopus
- Xenopus Proteins
- Zebrafish
- Zebrafish Proteins
- beta Catenin
- PubMed
- 8562427 Full text @ Mech. Dev.
Citation
Kelly, G.M., Erezyilmaz, D.F., and Moon, R.T. (1995) Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of ß-catenin. Mechanisms of Development. 53(2):261-273.
Abstract
Formation of the vertebrate axis may involve a Wnt signaling cascade similar to the Drosophila wingless pathway. Zebrafish wnt8 is a candidate for involvement in axis specification insofar as it is expressed maternally and when overexpressed it can induce goosecoid, a transcription factor normally expressed in the embryonic shield. In this study we demonstrate that beta-catenin, a cadherin associated protein in the Wnt pathway, is expressed maternally in zebrafish and is widely distributed in the early embryo. Overexpressing beta-catenin in early zebrafish embryos induces goosecoid and ntl, ultimately leading to a duplication of a complete secondary axis. These data are consistent with the involvement of beta-catenin in a Wnt signaling pathway which is involved in mesoderm induction in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping