PUBLICATION

Embryonic expression and DNA-binding properties of zebrafish pax-6

Authors
Amirthalingam, K., Lorens, J.B., Sætre, B.O., Salaneck, E., and Fjose, A.
ID
ZDB-PUB-961014-35
Date
1995
Source
Biochemical and Biophysical Research Communications   215: 122-128 (Journal)
Registered Authors
Fjose, Anders, Lorens, James B.
Keywords
none
MeSH Terms
  • Repressor Proteins
  • Gene Expression*
  • Rhombencephalon/embryology
  • Rhombencephalon/metabolism
  • Eye/embryology
  • Eye/metabolism
  • Zebrafish/embryology*
  • Animals
  • RNA, Messenger/metabolism
  • DNA/metabolism*
  • Paired Box Transcription Factors
  • Transcription Factors*
  • Polymerase Chain Reaction
  • Prosencephalon/embryology
  • Prosencephalon/metabolism
  • Homeodomain Proteins*
  • Eye Proteins
  • DNA Probes
  • DNA-Binding Proteins/genetics*
  • DNA-Binding Proteins/metabolism*
  • Nervous System/embryology
  • Nervous System/metabolism
  • In Situ Hybridization
(all 23)
PubMed
7575578 Full text @ Biochem. Biophys. Res. Commun.
Abstract
Zebrafish pax-6 (pax[zf-a]) and its murine homologue are structurally and functionally related to the Drosophila paired box gene eyeless, a master control gene for eye development. This report details the zebrafish pax-6 embryonic expression pattern both at the mRNA and protein level. Transcripts are first detected in the presumptive forebrain and hindbrain regions of the neural plate. After formation of the neural keel, Pax-6 protein accumulates within the same two domains. Expression is also observed in the optic vesicles and lens placodes, confirming that the Pax-6 protein is expressed in those areas of the eye where it is assumed to control differentiation. The relative DNA-binding affinity of the zebrafish Pax-6 protein to different categories of Pax recognition sites is shared with the murine homologue.
Genes / Markers
Figures
No images available
Expression
Phenotype
No data available
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Amirthalingam, K., Lorens, J.B., Sætre, B.O., Salaneck, E., and Fjose, A. (1995) Embryonic expression and DNA-binding properties of zebrafish pax-6. Biochemical and Biophysical Research Communications. 215:122-128.