PUBLICATION
The growth cones of identified motoneurons in embryonic zebrafish select appropriate pathways in the absence of specific cellular interactions
- Authors
- Eisen, J.S., Pike, S.H., and Debu, B.
- ID
- ZDB-PUB-961014-275
- Date
- 1989
- Source
- Neuron 2: 1097-1104 (Journal)
- Registered Authors
- Eisen, Judith S.
- Keywords
- none
- MeSH Terms
-
- Animals
- Axons/physiology*
- Axons/ultrastructure
- Electric Conductivity
- Embryo, Nonmammalian/physiology
- Membrane Potentials
- Motor Neurons/physiology*
- Motor Neurons/ultrastructure
- Zebrafish
- PubMed
- 2624743 Full text @ Neuron
Citation
Eisen, J.S., Pike, S.H., and Debu, B. (1989) The growth cones of identified motoneurons in embryonic zebrafish select appropriate pathways in the absence of specific cellular interactions. Neuron. 2:1097-1104.
Abstract
Developing motoneurons in zebrafish embryos follow a stereotyped sequence of axonal outgrowth and accurately project their axons to cell-specific target muscles. During axonal pathfinding, an identified motoneuron pioneers the peripheral motor pathway. Growth cones of later motoneurons interact with the pioneer via contact, coupling, and axonal fasciculation. In spite of these interactions, ablation of the pioneer motoneuron does not affect the ability of other identified motoneurons to select the pathways that lead to appropriate target muscles. We conclude that interactions between these cells during pathfinding are not required for accurate pathway selection.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping