PUBLICATION

The spt-1 mutation alters the segmental arrangement and axonal development of identified neurons in the spinal cord of the embryonic zebrafish

Authors
Eisen, J.S. and Pike, S.H.
ID
ZDB-PUB-961014-274
Date
1991
Source
Neuron   6: 767-776 (Journal)
Registered Authors
Eisen, Judith S.
Keywords
none
MeSH Terms
  • Animals
  • Axons/physiology
  • Cell Count
  • Interneurons/cytology
  • Interneurons/physiology
  • Mesoderm/physiology
  • Motor Neurons/cytology*
  • Motor Neurons/physiology
  • Muscles/embryology
  • Muscles/innervation
  • Mutation*
  • Neurons, Afferent/cytology
  • Neurons, Afferent/physiology
  • Spinal Cord/cytology
  • Spinal Cord/embryology*
  • Zebrafish/embryology*
  • Zebrafish/genetics
PubMed
2025428 Full text @ Neuron
Abstract
We examined the arrangement and development of identified neurons in zebrafish embryos homozygous for the mutation spt-1, which acts autonomously and specifically to alter the development of precursors of trunk segmented mesoderm, resulting in muscle-deficient myotomes. We found that the mutation alters the morphology, number, and arrangement of identified motoneurons. By transplanting identified motoneurons between wild-type and mutant embryos, we found that the effect of the mutation was nonautonomous. We suggest that the segmental arrangement and proper axonal development of motoneurons may result from interactions with segmented mesoderm.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping