PUBLICATION

Axis formation in zebrafish

Authors
Driever, W.
ID
ZDB-PUB-961014-240
Date
1995
Source
Current opinion in genetics & development   5: 610-618 (Review)
Registered Authors
Driever, Wolfgang
Keywords
none
MeSH Terms
  • Animals
  • Embryo, Nonmammalian/physiology*
  • Endoderm/physiology
  • Gastrula/physiology
  • Gene Expression
  • Mesoderm/physiology
  • Models, Biological
  • Signal Transduction
  • Xenopus/embryology
  • Zebrafish/embryology*
  • Zygote/physiology
PubMed
8664549 Full text @ Curr. Opin. Genet. Dev.
Abstract
Recent advances in our understanding of axis formation and patterning in zebrafish relate the developmental mode of this aspiring genetic model organism to higher vertebrates. The effect of UV irradiation and lithium treatment, as well as detailed early lineage analyses, have shed some light on dorsoventral axis formation. However, the molecular mechanism of axis formation, as well as the identity of a fish Nieuwkoop center, are still open issues. A Vg1 homolog is expressed in zebrafish, and activin as well as the mouse nodal gene product have been demonstrated to induce mesoderm and ectopic axes, respectively, in zebrafish. The zebrafish organizer is defined by the expression domains of goosecoid, axial, and lim1. The cyclops gene is involved in maintaining goosecoid expression in axial mesoderm of the head. Large mutagenesis screens provide the basis for a genetic analysis of axis formation.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping