PUBLICATION
Novel leiomodin 2b crispant zebrafish as a model for dilated cardiomyopathy
- Authors
- Antle, S.J., Schumacher, J.A.
- ID
- ZDB-PUB-260710-1
- Date
- 2026
- Source
- microPublication. Biology 2026: (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 42428299 Full text @ MicroPubl Biol
Citation
Antle, S.J., Schumacher, J.A. (2026) Novel leiomodin 2b crispant zebrafish as a model for dilated cardiomyopathy. microPublication. Biology. 2026:.
Abstract
Congenital heart disease (CHD) is highly prevalent in live births and requires concise diagnoses and treatment plans. Although there is a vast amount of genetics research in the field of CHD, there are still knowledge gaps regarding the gene networks surrounding heart development. A literature review revealed that mutation in Leiomodin 2 is associated with dilated cardiomyopathy in humans. We selected lmod2b for further molecular analysis. In situ hybridization was conducted throughout zebrafish embryonic development to investigate the expression pattern of lmod2b . To further understand the function of lmod2b , CRISPR-Cas9 gene editing was conducted to look for cardiac abnormalities.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping