PUBLICATION
Disinhibition of cerebellar output by loss of restless legs syndrome-associated gene MEIS1
- Authors
- Joo, W., Choi, J.W., Schier, A.F.
- ID
- ZDB-PUB-260618-4
- Date
- 2026
- Source
- Current biology : CB : S0960-9822(26)00648-2 (Journal)
- Registered Authors
- Joo, Will, Schier, Alexander
- Keywords
- MEIS1, RLS, cerebellum, restless legs syndrome, zebrafish
- MeSH Terms
- none
- PubMed
- 42309051 Full text @ Curr. Biol.
Citation
Joo, W., Choi, J.W., Schier, A.F. (2026) Disinhibition of cerebellar output by loss of restless legs syndrome-associated gene MEIS1. Current biology : CB. :S0960-9822(26)00648-2.
Abstract
Genome-wide association studies have identified risk variants for restless legs syndrome (RLS),1,2,3,4,5,6 but the behavioral functions and sites of action of the corresponding genes remain unknown. Here, we analyzed zebrafish mutants for candidate RLS genes and found that meis1b is required for normal locomotion behavior and cerebellar development. Neuronal manipulation experiments indicated that loss of meis1b perturbs locomotor behavior by generating abnormal cerebellar output-a mechanism reminiscent of movement disorders such as ataxia and dystonia.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping