PUBLICATION
Screening and characterization of a novel cupin-like polypeptide from Oyster (Ostrea gigas) and its anti-inflammatory effect via TAK1 mediated NF-κB pathway
- Authors
- Li, C., Xiang, Y., Jiang, T., Zhang, J., Xia, X., Liu, A.
- ID
- ZDB-PUB-260505-4
- Date
- 2026
- Source
- Food chemistry: X 36: 103884103884 (Journal)
- Registered Authors
- Keywords
- Anti-inflammatory activity, Cupin domain, Ostrea gigas, Polypeptide, TAK1
- MeSH Terms
- none
- PubMed
- 42078028 Full text @ Food Chem X
Citation
Li, C., Xiang, Y., Jiang, T., Zhang, J., Xia, X., Liu, A. (2026) Screening and characterization of a novel cupin-like polypeptide from Oyster (Ostrea gigas) and its anti-inflammatory effect via TAK1 mediated NF-κB pathway. Food chemistry: X. 36:103884103884.
Abstract
Inflammation is a natural host defense response to injury or infection, and seafood-derived polypeptides exhibit prominent anti-inflammatory potential with promising therapeutic applications. Here, we report the screening, characterization and anti-inflammatory evaluation of a novel cupin-like polypeptide OGP1-1 from Ostrea gigas. OGP1-1 exerted significant anti-inflammatory effects in RAW264.7 macrophages in vitro and in a transgenic zebrafish model in vivo. Chemical proteomics identified transforming growth factor-β-activated kinase 1 (TAK1) as the direct molecular target, and molecular docking and dynamics simulations confirmed stable binding within TAK1's activation loop. Mechanistic studies demonstrated that OGP1-1 exerts its anti-inflammatory effects by suppressing the TAK1-mediated NF-κB signaling pathway. Collectively, these findings position OGP1-1 as a novel cupin-like polypeptide with potent anti-inflammatory activity and high potential for development as a functional food ingredient in inflammation management.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping