PUBLICATION
Dynein axonemal assembly factors (dnaaf) 5 and 9 are expressed in ciliated organs of zebrafish embryos
- Authors
- Nayak, U., Sahoo, K., Swain, R.K.
- ID
- ZDB-PUB-260425-24
- Date
- 2025
- Source
- The International journal of developmental biology 69: 195202195-202 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 42029186 Full text @ Int. J. Dev. Biol.
Citation
Nayak, U., Sahoo, K., Swain, R.K. (2025) Dynein axonemal assembly factors (dnaaf) 5 and 9 are expressed in ciliated organs of zebrafish embryos. The International journal of developmental biology. 69:195202195-202.
Abstract
Dynein axonemal assembly factors (DNAAFs) play crucial roles in the formation and function of motile cilia, and their dysfunction often results in primary ciliary dyskinesia (PCD). We report the spatio-temporal expression patterns of dnaaf5 and dnaaf9 mRNA in zebrafish embryos, providing insight into their possible functions during development. We show that dnaaf5 and dnaaf9 mRNAs are expressed in motile ciliated tissues, such as the Kupffer's vesicle, pronephros, floor plate, brain and olfactory placode. The dnaaf5 and dnaaf9 crispants develop ciliopathic defects during zebrafish development. These data suggest that dnaaf5 and dnaaf9 may regulate motile cilia biogenesis and function in zebrafish. Our findings suggest functional redundancy and divergence among dynein arm assembly factors in vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping